Testing for familial correlation in age-at-onset

Testing for familial correlation in age-at-onset.

The analysis of family-study data sometimes focuses on whether a dichotomous trait tends to cluster in families. For traits with variable age-at-onset, it may be of interest to investigate whether age-at-onset itself also exhibits familial clustering. A complication in such investigations is that censoring by age-at-ascertainment can induce artifactual familial correlation in the age-at-onset o...

Familial correlations for age at onset and age at death in Huntington's disease.

Familial Mediterranean fever with onset at 66 years of age.

The patient was a 68-year-old woman who had experienced recurrent febrile episodes since 66 years of age. Despite various examinations and treatments, the etiology remained unclear. Further examinations following another referral failed to uncover the cause. Therefore, despite her age, it was presumed that she had familial Mediterranean fever. An analysis of the familial Mediterranean fever (ME...

Age of onset in familial cancer.

BACKGROUND Reliable estimates on the age of onset between familial and sporadic cancers are important for etiological understanding and clinical practice. Specific studies on the age of onset of familial cancer compared with sporadic cancer are less common than studies on familial risks and these are almost lacking for rare cancers. MATERIALS AND METHODS The Swedish Family-Cancer Database was...

Correlation between age at neutering and age at onset of hyperadrenocorticism in ferrets.

OBJECTIVE To determine prevalence of hyperadrenocorticism in ferrets in The Netherlands and evaluate age, sex, and age at neutering in affected ferrets. DESIGN Prevalence survey and retrospective study. ANIMALS 50 ferrets with hyperadrenocorticism and 1,267 ferrets without hyperadrenocorticism. PROCEDURE A questionnaire was sent to 1,400 members of a ferret-owners organization in The Neth...